Study identifies key cause of chronic leukemia progression

Courtesy EurekAlert! - Cancer  Wed, 03/03/2010 - 23:00

(Ohio State University Medical Center) Researchers have discovered a key reason why chronic myeloid leukemia progresses from its more-treatable chronic phase to a life-threatening phase called blast crisis.

The study indicates that CML progresses when immature white blood cells lose a molecule called miR-328 and this traps the cells in a rapidly growing, immature state.

The research should provide a better understanding of the blast-crisis stage of CML, and it suggests a possible new treatment strategy for the disease.

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