university of pennsylvania school of medicine

(University of Pennsylvania School of Medicine) Researchers at the Perelman School of Medicine at the University of Pennsylvania report that a short course of vaccination with an anti-HER2 dendritic cell vaccine made partly from the patient's own cells triggers a complete tumor eradication in nearly 20 percent of women with ductal carcinoma in situ, an early breast cancer.

(University of Pennsylvania School of Medicine) Just 30 percent the nation's state police agencies reported that they equip their vehicles with automated external defibrillators, and of those, nearly 60 percent of said only a minority of their fleet have the lifesaving devices on board, according to new research from the Perelman School of Medicine at the University of Pennsylvania that was presented today at the American Heart Association's annual Scientific Sessions (Abstract #10721).

(University of Pennsylvania School of Medicine) Even members of the lay public who have received CPR training are confused about how to perform the lifesaving skill and say they don't have confidence in their ability to do it properly, according to a study from the Perelman School of Medicine at the University of Pennsylvania which will be presented today at the American Heart Association's annual Scientific Sessions.

(University of Pennsylvania School of Medicine) A pandemic of ailments called the "allergic march" -- the gradual acquisition of overlapping allergic diseases that commonly begins in early childhood -- has frustrated both parents and physicians.

Now, in this week's Nature, a team of collaborating international scientists, identified that expression of the protein TSLP may influence susceptibility to multiple allergic diseases by regulating the maturation of basophils, an uncommon type of white blood cell.

(University of Pennsylvania School of Medicine) A physician panel in the primary care specialty of internal medicine has identified common clinical activities where changes in practice could lead to higher quality care and better use of finite clinical resources.

The study identifying the top five list of internal medicine activities appears online in the Archives of Internal Medicine.

(University of Pennsylvania School of Medicine) Patients who've been hurt in car or bike crashes, been shot or stabbed, or suffered other injuries are more likely to live if they arrive at the hospital on the weekend than during the week, according to new University of Pennsylvania School of Medicine research published in the March 21 issue of Archives of Surgery.

(University of Pennsylvania School of Medicine) For rodent pups, bonding with mom isn't hard-wired in the womb. It develops over the first few weeks of life, which is achieved by their maturing sense of smell, possibly allowing these mammals a survival advantage by learning to identify mother, siblings, and home.

Blending electrophysiological, biochemical and behavioral experiments, researchers demonstrated that neurons in the noses of mice mature after birth.

(University of Pennsylvania School of Medicine) A research team has deciphered a key step in an evolutionarily old branch of the immune response.

This system, called complement, comprises a network of proteins that "complement" the work of antibodies in destroying foreign invaders.

Complement proteins mark both bacterial and dying host cells for elimination by the body's cellular cleanup services and have been implicated in at least 30 diseases.

The findings provide a molecular scaffold for designing novel drug therapeutics.

(University of Pennsylvania School of Medicine) Overexpression or hyperactivation of ErbB cell-surface receptors drives the growth of many breast cancers.

Drugs, like Herceptin, that block the receptors' signals halt tumor progression in some patients. However, not all patients' tumors respond, with some becoming resistant over time.

Researchers found a protein called P-Rex1 is crucial for signal transmission from ErbB receptors and is overexpressed in nearly 60 percent of breast cancer samples tested.

(University of Pennsylvania School of Medicine) CPR quality is worse during in-hospital cardiac arrests occurring overnight than those that happen during the day, according to a new University of Pennsylvania School of Medicine study that will be presented at the American Heart Association's annual Scientific Sessions on Nov. 14.