therapeutic target

(University of Texas M. D. Anderson Cancer Center) M. D. Anderson researchers connect overexpression of tissue type transglutaminase with poor prognosis in ovarian cancer, identify the relevant pathway, and shut TG2 down with an siRNA liposomal nanoparticle.

They previously pinpointed TG2's role in resistant and metastatic melanoma and breast and pancreatic cancers.

This crucial protein fuels different cancers through different pathways.

Myostatin, a protein that blocks muscle growth, has shown promising results as a potential therapeutic target for treating muscular dystrophy in animal studies, where its inhibition led to increased muscle mass and strength.

A new study, the first to evaluate a myostatin inhibitor in patients, assessed its safety in adults with muscular dystrophy and found that it was well-tolerated.

The study was published today in Annals of Neurology, the official journal of the American Neurological Association.

A brain circuit that underlies feelings of stress and anxiety shows promise as a new therapeutic target for alcoholism, according to new studies by researchers at the National Institute on Alcohol Abuse and Alcoholism, part of the National Institutes of Health.In preclinical and clinical studies currently reported online in Science Express, NIAAA Clinical Director Markus Heilig, MD, PhD, and colleagues from the NIH, Lilly Research Laboratories, and University College in London.