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(Ohio State University Medical Center) A new study shows that a strain of measles virus engineered to kill cancer cells can prolong survival in a model of medulloblastoma that is disseminated in the fluid around the brain.

Treatment with the oncolytic virus called MV-GFP extended survival of animals with disseminated human medulloblastoma up to 122 percent, with treated animals surviving 82 days on average versus 37 days for controls.

Two of the eight treated animals were left cancer-free.

(Ohio State University Medical Center) Scientists from Brazil and the United States will discuss scientific studies of mutual interests and explore future partnerships at a three-day symposium in Washington on Oct. 24-26.

(Ohio State University Medical Center) Cloud computing is a term used to describe a system that allows easy access to a shared pool of resources.

The "cloud" acts like a virtual supercomputer that can pull together a cluster of other computers to work together to perform certain tasks.

The system works well when the data that are being stored, accessed and shared are in common formats that are universally "recognized" by end user tools.

But research data are often not captured or stored in formats that are compatible.

(Ohio State University Medical Center) Indirubin, the active ingredient in a traditional Chinese herbal medicine, might offer a new strategy for treating glioblastoma, a deadly form of brain cancer.

A new study shows that indirubin both blocks the migration of glioblastoma cells, preventing their spread to other areas of the brain, and the migration of endothelial cells, preventing them from forming the new blood vessels the tumor needs to grow.

(Ohio State University Medical Center) New research proves that a change in a particular gene can identify which patients with a specific kind of brain cancer will respond better to treatment.

Testing for the gene can distinguish patients with a more- or less-aggressive form of glioblastoma, the most common and an often-fatal type of primary brain cancer, and this can help guide therapy.

The prospective study looked for a change in the MGMT gene in tumors from 833 glioblastoma patients.

(Ohio State University Medical Center) Researchers have identified characteristic patterns of molecules called microRNA in the blood of people with lung cancer that might reveal both the presence and aggressiveness of the disease, and perhaps who is at risk of developing it.

These patterns may be detectable up to two years before the tumor is found by computed tomography (CT) scans.

The findings could lead to a blood test for lung cancer.

(Ohio State University Medical Center) A new study suggests that combining two experimental anticancer peptide agents might simultaneously block formation of new tumor blood vessels while also inhibiting the growth of tumor cells.

The findings suggest that the double hit can stifle tumor progression, avoid drug resistance and cause few side effects, say the researchers who developed the agents and evaluated their effectiveness in laboratory and animal tests.

(Ohio State University Medical Center) A study published in JAMA shows for the first time that the three most common chromosome changes seen in chronic lymphocytic leukemia (CLL) disrupt a molecular network that includes several important genes and strongly influence the outcome of the disease.

The study provides important new information about how CLL develops and could improve CLL diagnose, and it identifies new molecular targets for the development of new treatments.

(Ohio State University Medical Center) A new study provides a rational for treating breast cancer by combining two kinds of targeted agents, one that inhibits an overactive, cancer-causing signaling pathway in cancer cells and one that reverses changes that silence genes that normally prevent cancer.

Both types of agents are currently available and being evaluated individually in clinical trials.

(Nationwide Children's Hospital) Repairing small, seemingly benign holes in a child's heart may be more clinically important than previously thought, as dysfunction could be lurking out of sight.

These are the findings from a study conducted by doctors and researchers at Nationwide Children's Hospital and the Ohio State University Medical Center examining a subset of the most common form of congenital heart disease, ventricular septal defect.