spring harbor laboratory

(Cold Spring Harbor Laboratory) A team of scientists at Cold Spring Harbor Laboratory has found that a protein called Scribble, originally discovered as a cell-shape regulator in fruit flies and worms, is an important regulator of breast cancer.

They report that Scribble normally directs breast epithelial cells to form the structures that give breast tissue its shape and thereby resist cancer formation.

When Scribble stops functioning, the tissue loses its shape and cancers ensue.

(Cold Spring Harbor Laboratory) CSHL scientists report their discoveries of a previously unknown mechanism in the nucleus that processes non-coding RNA molecules to generate what might be a new class of small RNAs.

(Cold Spring Harbor Laboratory) In the Nov. 15 issue of G&D, Dr. Kenneth Dorshkind and colleagues at the David Geffen School of Medicine have identified two genes -- p16(Ink4a) and Arf -- that sensitize lymphoid progenitor cells to the effects of aging, and confer resistance to leukemogenesis.

(Cold Spring Harbor Laboratory) A research team at Cold Spring Harbor Laboratory is clarifying a previously unappreciated way that cellular processes are disrupted in cancer.

Following upon previous work showing that a splicing factor called SF2/ASF can induce tumors in cell cultures, the team now shows that the same splicing factor induces changes in proteins in a pathway called PI3K-mTOR well known for its involvement in cancers.

(Cold Spring Harbor Laboratory) Although post-reproductive life in humans is often associated with decline and a loss of powers, an analogous state in certain cells -- called senescence -- is proving to be one of ironic potency.

Scientists at Cold Spring Harbor Laboratory today reported that a particular class of senescent liver cells orchestrates a sequence of events in living mice that can limit fibrosis, a natural response of the liver to acute damage.

(Cold Spring Harbor Laboratory) Scientists at Cold Spring Harbor Laboratory have taken the search for cancer-causing genes an important step forward.

In a newly published paper, they confirm that a gene called DLC1 is a tumor suppressor. They have demonstrated in living mice that its deletion, inactivation or loss precipitates events culminating in an aggressive type of liver cancer closely related to common human epithelial cancers of the liver.

(Cold Spring Harbor Laboratory) Using a common virus as a tool for investigating abnormal cell proliferation, a team led by scientists at Cold Spring Harbor Laboratory has succeeded in clarifying an intricate series of biochemical steps that shed light on a way that cancer can begin.