rna interference

(University of Massachusetts Medical School) Researchers at the University of Massachusetts Medical School report on a cellular pathway in the deadly brain cancer malignant glioma, a pathway essential to the cancer's ability to grow -- and a potential target for therapy that would stop the cancer's ability to thrive.

(California Institute of Technology) A Caltech-led team of researchers and clinicians has published the first proof that a targeted nanoparticle -- used as an experimental therapeutic and injected directly into a patient's bloodstream -- can traffic into tumors, deliver double-stranded small interfering RNAs, and turn off an important cancer gene using a mechanism known as RNA interference.

Moreover, the team provided the first demonstration that this new type of therapy can make its way to human tumors in a dose-dependent fashion.