protease inhibitors

(Yates Public Relations) Avila, a biotechnology company developing novel targeted covalent drugs, has published research in Nature Chemical Biology demonstrating the first-ever selective irreversible inhibition of a viral protease using a targeted covalent drug.

In the paper titled "Selective Irreversible Inhibition of a Protease by Targeting a Non-Catalytic Cysteine," Avila designed covalent irreversible protease inhibitors whose unique pharmacology yields performance superior to conventional protease inhibitors with respect to selectivity, potency and duration of action.

VIENNA (MedPage Today) -- Researchers said here that therapeutic drug monitoring to assure proper levels of protease inhibitors are on board should be considered when non-nucleoside reverse transcriptase inhibitors are added to antiretroviral regimens for experienced human immunodeficiency virus (HIV) patients.

BOSTON (MedPage Today) -- Two investigational drugs targeting the hepatitis C virus (HCV) protease enzyme helped patients clear the virus with once-daily dosing, in contrast with the three-times-per-day schedule needed for similar drugs in development.