mutations

For the first time, researchers have decoded all the genes of a person with cancer and found a set of mutations that may have caused the disease or aided its progression.

(Journal of Clinical Investigation) This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published Oct. 23, 2008, in the JCI: "Two drugs are better than one at targeting tumors with B-RAF mutations;" "A new regulator in the liver: miR15a controls the development of cysts; and Tracking down the human equivalent of the mouse protein mFc-gamma-RIV."

(Society for General Microbiology) Scientists have discovered how bird flu adapts in patients, offering a new way to monitor the disease and prevent a pandemic, according to research published in the August issue of the Journal of General Virology.

PHILADELPHIA -- Some patients with gastrointestinal stromal tumors (GIST) who are imatinib (Gleevec)-resistant don't respond because they are missing the mutations in two genes that are usually integral to the illness.

Now researchers here have found out what may be causing their disease.

PHILADELPHIA -- Some patients with gastrointestinal stromal tumors (GIST) who are imatinib (Gleevec)-resistant don't respond because they are missing the mutations in two genes that are usually integral to the illness.

Now researchers here have found out what may be causing their disease.

Patients with schizophrenia are three to four times as likely as healthy people to harbor large mutations in genes that control brain development, and many of those glitches are unique to each patient, researchers reported yesterday.