massachusetts general hospital

(Massachusetts General Hospital) Investigators at the Massachusetts General Hospital Cancer Center have defined the role of a recently identified gene abnormality - rearrangements in the ROS1 gene - in a deadly form of lung cancer.

ROS1-rearranged tumors represent one to two percent of non-small-cell lung cancers, the leading cause of cancer death in the US.

The researchers also show that ROS1-driven tumors can be treated with crizotinib and describe the remarkable response of one patient to crizotinib treatment.

(Rutgers University) Rutgers University and Massachusetts General Hospital investigators have developed a novel strategy to protect the liver from drug-induced injury and improve associated drug safety.

The team reports that inhibiting a type of cell-to-cell communication can protect against damage caused by liver-toxic drugs such as acetaminophen.

(Massachusetts General Hospital) A major international study has identified a novel gene mutation that appears to increase the risk of both inherited and sporadic cases of malignant melanoma, the most deadly form of skin cancer.

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(American Friends of Tel Aviv University) Through a clinical product called NurOwn, research from Tel Aviv University is turning bone marrow stem cells into astrocyte-like cells which are responsible for the well-being of the brain's neurons.

Trials for the technology, which has the potential to treat a broad range of neurodegenerative conditions, are now planned for Massachusetts General Hospital.

(Massachusetts General Hospital) Children who live in households where they are exposed to tobacco smoke miss more days of school than do children living in smoke-free homes, a new nationwide study confirms.

The report finds these children have higher rates of respiratory illnesses that can be caused by second-hand smoke and details the probable economic costs of their increased school absence.

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(Massachusetts General Hospital) According to a new study released online today, a majority of Americans, including most African Americans, stand together in support of banning menthol in cigarettes just as other cigarette flavorings have now been banned by the FDA.

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(Massachusetts General Hospital) Massachusetts General Hospital investigators have developed a novel system for delivery of growth factors to chronic wounds such as pressure sores and diabetic foot ulcers.

The team from the MGH Center for Engineering in Medicine fabricated nanospheres containing keratinocyte growth factor fused with elastin-like peptides.

When suspended in a fibrin gel, the nanoparticles improved the healing of deep skin wounds in diabetic mice.