journal of clinical investigation

(Journal of Clinical Investigation) This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published Oct. 23, 2008, in the JCI: "Two drugs are better than one at targeting tumors with B-RAF mutations;" "A new regulator in the liver: miR15a controls the development of cysts; and Tracking down the human equivalent of the mouse protein mFc-gamma-RIV."

(Journal of Clinical Investigation) This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, Oct. 16, 2008, in the JCI: Molecular defect for one form of male factor infertility uncovered; Take it down a Notch(1): new role for Notch1 in facilitating melanoma development; Platelets go with their gut feeling, helping promote intestinal inflammation; and others.

(Journal of Clinical Investigation) This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, Oct. 9, 2008, in the JCI: A low-cholesterol diet leaves a bitter taste in the gut; A real-time view of blood flow through the pancreas; The protein NFATc1: a master controller of bone destruction; Slow, slow, quick, quick, slow: molecular insight into muscle fiber composition; and others.

(Journal of Clinical Investigation) This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, Oct. 1, 2008, in the JCI, including: Loss of the protein target of lithium disrupts normal mouse embryonic heart development; Restoring PTEN protein function in leukemic cells; Pinpointing a crucial role in the heart for one HDAC protein, HDAC3; and others.

(Journal of Clinical Investigation) This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, September 5, 2008, in the JCI: "How STDs increase the risk of becoming infected with HIV"; "HIV-stimulated immune cells generate cells with immunosuppressive properties"; "How immune cells help tumors grow blood vessels"; "Type 2 diabetes under stress"; and "Stuck on you: FGF proteins help ensure cells lining blood vessels stick together."

(Journal of Clinical Investigation) Individuals who have a sexually transmitted disease and women with yeast and bacterial vaginal infections have an increased risk of becoming infected with HIV if exposed to the virus through sexual contact.

Research published in the Journal of Clinical Investigation has now provided a new explanation as to how and why STDs have this effect.

(Journal of Clinical Investigation) This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, Aug. 14, 2008, in the JCI, including: "Lessons from yeast: A possible cure for Parkinson's disease?"; "Inhibitors of the molecule PI3K throw one form of leukemia a curveB-ALL"; "Drosophila provide insight into human bacterial infections"; "Beating of the heart: differentially regulated in atria and ventricles"; and others.

(Journal of Clinical Investigation) This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, Aug. 1, 2008, in the JCI, including: Overcoming inhibitors of cell death improves cancer therapy efficacy; A mechanism for the development of obesity-associated conditions; How inflammatory cells get from the blood to the site of injury; Some types of leukemia are addicted to Notch proteins; and others.

(Journal of Clinical Investigation) Individuals with one of the most aggressive types of brain tumor have an extremely poor prognosis.

Although some patients with GBM respond to treatment with drugs known as RTK inhibitors, most subsequently relapse after only a short time.

New data, have now provided insight into the mechanism by which GBM cells become resistant to RTK inhibitors and suggest a way to improve the efficacy of RTK inhibitors as a treatment for GBM.

(Yale University) A new study by researchers at Yale School of Medicine could explain why the cold and flu virus symptoms that are often mild and transient in non-smokers can seriously sicken smokers.

Published in the Journal of Clinical Investigation, the study also identified the mechanism by which viruses and cigarette smoke interact to increase lung inflammation and damage.