(Society for Experimental Biology and Medicine) The paper by Croix and coauthors demonstrates that both microbial and host inflammatory factors modulate sulfomucin production in the human goblet cell line.
Sulfomucins provide crucial protection to the intestinal mucosa and their expression is altered in mucosal lesions of both inflammatory bowel disease and colorectal cancer.
The present data demonstrate for the first time that the Golgi sulfotransferases responsible for mucin sulfation are highly sensitive to inflammatory cues.