hydrogen peroxide

(University of Wisconsin-Madison) University of Wisconsin-Madison researchers now have discovered the molecular sensor that detects wound-induced hydrogen peroxide and orchestrates the marshaling of neutrophils and other immune cells, or leukocytes, including those that affect tumors.

(Johns Hopkins Medical Institutions) Working with lab cultures and mice, Johns Hopkins scientists have found that a strain of the common gut pathogen Bacteroides fragilis causes colon inflammation and increases activity of a gene called spermine oxidase in the intestine.

The effect is to expose the gut to hydrogen peroxide -- the caustic, germ-fighting substance found in many medicine cabinets -- and cause DNA damage, contributing to the formation of colon tumors, say the scientists.

(DOE/Lawrence Berkeley National Laboratory) Berkeley Lab scientists have developed a probe for monitoring hydrogen peroxide levels in mice that enables them to track the progression of cancerous tumors or infectious diseases without harming the animals or even having to shave their fur.

This new probe is based on luciferase, the enzyme that gives fireflies their glow.

(Massachusetts Institute of Technology) MIT chemical engineers have built a sensor array that, for the first time, can detect single molecules of hydrogen peroxide emanating from a single living cell.

(University of Southern California) Common household chemical, also made naturally by living cells, appears to be involved in regulation of circadian rhythms, according to new study in PLoS ONE.

(Burnham Institute) Researchers at the Burnham Institute for Medical Research have discovered that reactive oxygen species, such as superoxide and hydrogen peroxide, play a key role in forming invadopodia, cellular protrusions implicated in cancer cell migration and tumor metastasis.

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