(University of Washington) Scientists detected organizational shifts away from the normal lean state in the gut flora of people who were obese.
The differences relate to how the microbial community interacts with the human gut environment, rather than variations in its core energy-use processes.
Researchers made the discovery by studying the gut's massive collection of microorganisms as a complex, integrated biological system, rather than as a set of separate species, and by constructing computer models of genetic interplays and energy use in the microbial communities.