helicobacter pylori

(American Society for Microbiology) Helicobacter pylori, the bacterium largely associated with gastritis and peptic ulcers in humans, may invade and replicate in gastric epithelial cells say researchers from China.

(American Society for Microbiology) Scientists have determined that Helicobacter pylori, the bacterium that causes peptic ulcers and some forms of stomach cancer, requires the vitamin B6 to establish and maintain chronic infection, according to research published this week in the online journal mBio.

This finding, along with the identification of the enzyme the microbe requires to utilize the vitamin, could lead to the development of an entirely new class of antibiotics.

(Max-Planck-Gesellschaft) A breakthrough in decoding gene regulation of Helicobacter pylori has been made by an international research team led by Jorg Vogel of the Max Planck Institute for Infection Biology in Berlin.

Using a newly developed sequencing technique, the researchers discovered 60 small ribonucleic acids -- tiny RNA-particles which can regulate genes -- in the genome of this human pathogen.

These findings could facilitate the development of new therapeutic strategies against this widespread pathogen.

(World Journal of Gastroenterology) Helicobacter pylori has been accepted as an important pathogen inducing gastric cancer.

A research group from Taiwan investigated optimal intervention point of Celecoxib, to inhibit H. pylori-associated gastric carcinogenesis in Mongolian gerbils.

They found that short-term use resulted in less severe inflammation and inhibited the invasion degree of gastric cancer.

Therefore, Celecoxib could be used in the later stages of H. pylori infection to achieve safe and effective chemoprevention of gastric adenocarcinoma.

SAN DIEGO (MedPage Today) -- An investigational, four-drug regimen for the ulcer-causing Helicobacter pylori infection led to a significantly higher eradication rate than the current standard in previously untreated patients in a multi-center, randomized trial reported here.

(University of Gothenburg) Helicobacter pylori survives in the body by manipulating important immune system cells.

This is shown in a thesis from the Sahlgrenska Academy at the University of Gothenburg, Sweden. The discovery may lead to new treatments against the common peptic ulcer bacterium.