(Elsevier Health Sciences) The trefoil factor 3 (TFF3) protein protects and maintains the integrity of the epithelial surface in the normal breast.
New research has found that while TFF3 protein expression is higher in well-differentiated low grade tumors and therefore associated with features of a good prognosis, it has a more sinister role in breast cancer invasion and metastasis.
The report is published in the March issue of the American Journal of Pathology.