cystic fibrosis

WASHINGTON (AP) -- The first drug that treats the root cause of cystic fibrosis won approval Tuesday, offering a life-changing treatment for a handful of patients with the deadly illness and broader hope for thousands more patients with the inherited disease....

Drug approved to treat cystic fibrosis' root cause Associated Press

(American Thoracic Society) The lung clearance index is a sensitive noninvasive marker of early lung disease in young children with cystic fibrosis, according to a new study from Australian researchers.

(Northwestern University) Two related studies from Northwestern University offer new strategies for tackling the challenges of preventing and treating diseases of protein folding, such as Alzheimer's, Parkinson's and Huntington's diseases, ALS, cystic fibrosis, cancer and type 2 diabetes.

The research identifies new genes and pathways that prevent protein misfolding and toxic aggregation, keeping cells healthy, and also identifies small molecules with therapeutic potential that restore health to damaged cells, providing new targets for drug development.

(MedPage Today) -- A novel drug that targets a genetic mutation that is a cause of cystic fibrosis appears to be effective in children -- a finding that follows by a day a report that the drug improves lung function in adults with the disease.

(American Physiological Society) When researchers discovered the primary genetic defect that causes cystic fibrosis (CF) back in 1989, they opened up a new realm of research into treatment and a cure for the disease.

Since then, scientists have been able to clone the defective gene and study its effects in animals. Now researchers at the University of North Carolina at Chapel Hill have developed a technique for observing the defects at work in human tissue donated by patients with CF.

WASHINGTON (AP) -- A growing shortage of medications for a host of illnesses - from cancer to cystic fibrosis to cardiac arrest - has hospitals scrambling for substitutes to avoid patient harm, and sometimes even delaying treatment....

(University of North Carolina School of Medicine) A team of researchers, including a number from the University of North Carolina at Chapel Hill School of Medicine, have pinpointed regions of the genome that contribute to the debilitating lung disease that is the hallmark of cystic fibrosis.

Genetic tests for conditions such as cystic fibrosis should be available before people become pregnant, says the government's advisory body on genetics.

(Scripps Research Institute) Over the last years, two teams of researchers at the Scripps Research Institute have steadily built a model of how a powerful DNA repair complex works.

Now, their latest discovery provides revolutionary insights into the way the molecular motor inside the complex functions -- findings they say may have implications for treatment of disorders ranging from cancer to cystic fibrosis.