colon cancer

(University of California - Riverside) A research team led by cell biologists at the University of California, Riverside has uncovered a new insight into colon cancer, the third leading cause of cancer-related deaths in the United States.

The team analyzed human colon cancer specimens and found that in nearly 80 percent of them the variants of a gene (HNF4A) are out of balance.

This imbalance appears to be the result of a complex, multi-step process by an enzyme (Src kinase).

(University of Colorado Denver) "Stop-and-go" dosing along with calcium and magnesium supplements reduce neurological side effects of oxaliplatin use with metastatic colon cancer patients.

SAN FRANCISCO (MedPage Today) -- Curative therapy is still a possibility, even if a colon cancer patient is seen for the first time in the emergency department with acute symptoms, researchers said here.

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(MedPage Today) -- Most patients with intestinal obstructions related to incurable colon cancer were able to avoid colostomies and enjoyed improved function when they received self-expanding metal colonic stents, Italian researchers said.

(University of Florida) Scientists have modified a toxic chemical produced by tiny marine microbes and successfully deployed it against laboratory models of colon cancer.

More work is needed before a human treatment can be considered, but it appears to be a novel way to kill tumor cells.   

(UT Southwestern Medical Center) Researchers at UT Southwestern Medical Center say there are at least 70 genetic mutations involved in the formation of colon cancer, far more than scientists previously thought.

(Johns Hopkins Medical Institutions) Using the latest gene sequencing tools to examine so-called epigenetic influences on the DNA makeup of colon cancer, a Johns Hopkins team says its results suggest cancer treatment might eventually be more tolerable and successful if therapies could focus on helping cancer cells get back to normal in addition to strategies for killing them.

One in three adults who have been screened for colon cancer fail to follow up with repeat screenings as recommended, according to a new survey.

(Helmholtz Association of German Research Centres) A compound that for about 60 years has been used as a drug against tapeworm infection is also apparently effective against colon cancer metastasis, as studies using mice have shown.

The compound silences a gene that triggers the formation of metastases in colon cancer. Researchers in Berlin, Germany, made this discovery in collaboration with researchers in the USA.

Plans are already underway to conduct a clinical trial.