brain tumors

(Canale Communications) Tocagen Inc. today announced the publication of data showing the company's investigational treatment for high grade glioma eradicates brain tumors and provides a dramatic survival benefit in mouse models of glioblastoma.

Almost all mice receiving the top dose of Toca 511 followed by 5-FC were still alive at 180 days, which was the termination date for the experiment, whereas all control mice died by day 43.

The article was published today in the February issue of the Neuro-Oncology journal.

(St. Jude Children's Research Hospital) Researchers studying a rare, lethal childhood tumor of the brainstem discovered that nearly 80 percent of the tumors have mutations in genes not previously tied to cancer.

Early evidence suggests the alterations play a unique role in other aggressive pediatric brain tumors as well.

(Helmholtz Association of German Research Centres) Scientists of the German Cancer Research Center and Heidelberg University Hospitals have tested a combination of radiation treatment and a substance that blocks the transforming growth factor beta for treating glioblastoma.

In the mouse model, this combination therapy was found to be more effective in slowing down the growth of such malignant brain tumors and to prolong survival of the animals.

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(Brown University) Subjects with somewhat elevated levels of antibodies produced to fight allergens were less likely to go on to develop brain tumors, according to a new study.

The study adds to evidence from prior studies, but some questions still remain.

(NIH/National Institute of Neurological Disorders and Stroke) Brain tumors called gliomas are often associated with seizures, but why the seizures occur and how to effectively treat them have been elusive.

An NIH-funded team has found that human gliomas implanted in mice release excess levels of the brain chemical glutamate, overstimulating neurons near the tumor and triggering seizures.

Sulfasalazine, a drug on the market for treating certain inflammatory disorders, reduced seizures in the mice.

(Virginia Commonwealth University) A single compound with dual function -- the ability to deliver a diagnostic and therapeutic agent -- may one day be used to enhance the diagnosis, imaging and treatment of brain tumors, according to findings from Virginia Commonwealth University and Virginia Tech.

(Mary Ann Liebert, Inc./Genetic Engineering News) Novel tools and methods for delivering therapeutic genes to cells in the central nervous system hold great promise for the development of new treatments to combat incurable neurologic diseases.

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