How proteins talk to each other

Courtesy EurekAlert! - Medicine and Health  Sun, 09/20/2009 - 22:00

(Burnham Institute) Investigators at Burnham Institute for Medical Research have identified novel cleavage sites for the enzyme caspase-3 (an enzyme that proteolytically cleaves target proteins).

Using an advanced proteomic technique called N-terminomics, Guy Salvesen, Ph.D., professor and director of the Apoptosis and Cell Death Research program of Burnham's NCI-designated Cancer Center, and colleagues determined the cleavage sites on target proteins and found, contrary to previous understanding, that caspase-3 targets a-helices as well as unstructured loops.

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