CHEO RI study uses sophisticated genetic engineering to improve ...

Courtesy EurekAlert! - Medicine and Health  Tue, 10/06/2009 - 22:00

(Children's Hospital of Eastern Ontario Research Institute) A study to be published today in the leading international journal Cell Metabolism describes how a research group led by Dr.

Robert Screaton, who holds the Canada Research Chair in Apoptotic Signaling at the University of Ottawa, used sophisticated genetic engineering to remove or "knock out" the Lkb1 gene from beta cells of laboratory mice.

The result was an increase in both the size and number of beta cells, as well as greater amounts of insulin stored and released by the cells.

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