Caltech-led team provides proof in humans of RNA interference us...

Courtesy EurekAlert! - Cancer  Sat, 03/20/2010 - 22:00

(California Institute of Technology) A Caltech-led team of researchers and clinicians has published the first proof that a targeted nanoparticle -- used as an experimental therapeutic and injected directly into a patient's bloodstream -- can traffic into tumors, deliver double-stranded small interfering RNAs, and turn off an important cancer gene using a mechanism known as RNA interference.

Moreover, the team provided the first demonstration that this new type of therapy can make its way to human tumors in a dose-dependent fashion.

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